5 Simple Techniques For https://www.ceesdekker.net
5 Simple Techniques For https://www.ceesdekker.net
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Human Rad51 filaments on double- and solitary-stranded DNA: correlating frequent and irregular kinds with recombination functionality.
[Laughs] ‘It absolutely was unquestionably a fantastic chance! At the time, I had been perfectly informed that it could go Erroneous Which I could grow to be a lot less effective, but I just ignored that. Curiosity has normally been my strongest driving drive. And by chance all of it worked out.’
Our perform was speedily followed up by Other people, most notably by Phaedon Avouris and colleagues at IBM, who in October 1998 printed their findings on transistors produced from single- and multi-walled carbon nanotubes in Applied Physics Letters.
2015, discovery that condensin is really a highly adaptable protein construction; and first detection of DNA knots applying nanopores
SMC complexes can pass physical roadblocks larger than their ring dimensions, indicating a nontopological mechanism for DNA loop extrusion
All parameters ended up the identical for every panel In this particular video, aside from the initial placement of your 6hb rod (proven in blue) on the nanopore. Simulations that terminated early as a consequence of translocation with the rod from the pore are marked by a gray qualifications.
Move-pushed rotary motors like windmills and water wheels push useful procedures in human Modern society. Although examples of this sort of rotary motors also attribute prominently in mobile biology, their artificial development within the nanoscale has remained challenging. Right here we exhibit flow-driven rotary motion of a self-organized DNA nanostructure that's docked onto a nanopore in a thin strong-state membrane. An elastic DNA bundle self-assembles into a chiral conformation upon phoretic docking on to the solid-state nanopore, and subsequently shows a sustained unidirectional rotary movement of up to twenty rev s−one.
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Bulk-area coupling identifies the mechanistic relationship in between Min-protein styles in vivo and in vitro
Testing pseudotopological and nontopological versions for SMC-pushed DNA loop extrusion against roadblock-traversal experiments
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Developments in nanotechnology during the nineteen nineties made building electronic devices from one molecules a possibility. Cees Dekker recounts how his team created a room-temperature transistor according to a single carbon nanotube.
The biophysicist from Delft – who has actually been Among the most cited researchers inside the Netherlands For many years – requires his obligation to add on the explanation and popularisation of his function at the border of physics and biology exceptionally severely and often appears during the media; if not to mention his perform, then about the relationship concerning science and his Christian religion.